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线粒体DNA激活cGAS-STING信号通路促进肺部炎性疾病的研究进展

ZHEN Ning-xin,CUI Wei,TIAN Bao-ping

Chinese Journal of Pathophysiology（2022）

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Abstract
免疫系统由先天性免疫和适应性免疫组成.先天免疫反应作为机体免疫防御的第一道防线,能通过模式识别受体(pattern recognition receptors,PRRs)迅速识别入侵体内的病原体及组织或细胞受到损伤、低氧等因素刺激后释放的内源性损伤相关分子模式(damage-associated molecular patterns,DAMPs),进而产生快速而非特异性的免疫应答[1].
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