坏死性凋亡在肝缺血再灌注损伤中作用的研究进展
Chinese Journal of Histochemistry and Cytochemistry(2020)
Abstract
坏死性凋亡是一种精细调控的坏死形式,由死亡受体与配体结合介导,在其发生过程中,受体相互作用蛋白家族(receptor-interacting proteins,RIPs)和混合谱系激酶结构域样蛋白(mixed lineage kinase domain-like protein,MLKL)发挥关键作用.越来越多的研究证明,坏死性凋亡引起的细胞损伤和炎症反应在肝脏缺血再灌注损伤(hepatic ischemia-reper-fusion injury,HIRI)中发挥重要作用.本文综述了坏死性凋亡的机制及其在HIRI中的作用,并对坏死性凋亡的抑制剂作简要总结.
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