抗SOX1、Yo、Zic4多重抗体阳性Lambert-Eaton肌无力综合征1例
Chinese Journal of Practical Internal Medicine（2021）
Abstract
Lambert-Eaton肌无力综合征(LEMS)是一种罕见的自身免疫性神经肌肉接头病,是经典的神经系统副肿瘤综合征(PNS)之一.约60％的LEMS患者与肿瘤相关,大多数患者患有小细胞肺癌(SCLC)[1].在已知的PNS中,神经元抗体副肿瘤的病因已得到证实,并能够指导肿瘤的筛查[2].多重抗体阳性的LEMS在临床上十分罕见,现报道1例以四肢乏力为主诉,完善PNS抗体筛选,诊断为LEMS伴VGCC、SOX1、Yo及Zic4多重抗体阳性的SCLC患者.
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