血清miR⁃199a⁃5p、miR⁃378a⁃3p水平与婴幼儿增殖期面部血管瘤普萘洛尔停药后复发的关系
Journal of Dental Prevention & Treatment(2022)
Abstract
目的 探讨血清miR?199a?5p、miR?378a?3p水平与婴幼儿增殖期面部血管瘤普萘洛尔停药后复发的关系.方法 增殖期面部血管瘤患儿93例,均接受普萘洛尔治疗,随访治疗后血管瘤复发情况,并将患儿分为复发组(23例)和无复发组(70例).治疗前、后采集静脉血,qRT?PCR检测血清miR?199a?5p、miR?378a?3p表达,分析血清miR?199a?5p、miR?378a?3p表达与增殖期面部血管瘤婴幼儿普萘洛尔停药后复发的关系.结果 无复发组治疗后血清miR?199a?5p、miR?378a?3p表达较治疗前增高(P<0.05),复发组治疗后血清miR?199a?5p、miR?378a?3p表达与治疗前比较差异无统计学意义(P>0.05).复发组治疗后血清miR?199a?5p、miR?378a?3p表达低于无复发组(P<0.05).治疗后瘤体分级Ⅲ~Ⅳ级患儿血清miR?199a?5p、miR?378a?3p表达高于Ⅰ~Ⅱ级患儿(P<0.05).Logistic回归分析结果显示miR?199a?5p低表达、miR?378a?3p低表达、治疗后瘤体分级Ⅰ~Ⅱ级是增殖期面部血管瘤婴幼儿普萘洛尔停药后复发的危险因素(P<0.05).结论 血清miR?199a?5p、miR?378a?3p低表达与增殖期面部血管瘤婴幼儿普萘洛尔停药后血管瘤复发有关.
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Key words
micro ribonucleic acid,mir-199a-5p,mir-378a-3p,propranolol,infant,hemangioma,recurrence,endothelial cell proliferation
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