Ibalizumab治疗成人多耐药HIV-1感染的研究进展
Journal of Modern Clinical Medicine(2022)
Abstract
Ibalizumab是一类首个作用于靶向CD4受体结构域2的重组单克隆抗体,可阻断HIV-1进入宿主细胞,阻止通过细胞-细胞融合发生的病毒传播.本文就Ibalizumab治疗成人多耐药HIV-1感染的作用机制、药效学及药代动力学、治疗有效性及安全性等方面的研究进展进行综述,旨在为治疗成人多耐药HIV-1感染提供参考.
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