Interdisciplinary model-informed drug development for extending duration of elagolix treatment in patients with uterine fibroids.

Denise Beck,Insa Winzenborg,Wei Gao,Nael M Mostafa,Stephanie E Chiuve,Charlotte Owens,Mohamad Shebley

British journal of clinical pharmacology（2022）

引用 6|浏览10

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摘要

The elagolix integrated exposure-BMD analysis and translation to fracture risk provided an interdisciplinary model-informed drug development framework for clinical benefit-risk evaluation and enabled approval of longer treatment duration to benefit the patient.

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关键词

bone mineral density,elagolix,exposure-response,femoral neck,uterine fibroids

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