Saikosaponin D attenuates metabolic associated fatty liver disease by coordinately tuning PPARα and INSIG/SREBP1c pathway

Yiqing Gu,Shuni Duan,Mingning Ding,Qi Zheng,Guifang Fan,Xiaojiaoyang Li,Yijie Li,Chuanyang Liu,Rong Sun,Runping Liu

Phytomedicine（2022）

引用 8|浏览20

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摘要

•Saikosaponin d (SSd) inhibits SREBP1c maturation by inducing INSIGs.•SSd is a potential PPARα agonist and activates INSIGs expression.•SSd modulates FA metabolism in the liver and both white and brown adipose tissue.

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关键词

Fatty acid metabolism,Saikosaponins D,Metabolic associated fatty liver disease,PPARα,SREBP1c,INSIGs

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