应用脑脊液流式细胞术诊断两例儿童ALL中枢复发
Journal of China Pediatric Blood and Cancer（2022）
Abstract
1 病历资料 患儿黄XX,女,初诊时6岁,2019-08-02首次入住我院.初发时外周血WBC 358×109/L;骨髓MICM分型:ALL-T,染色体核型正常,伴NOTCH1基因阳性.因诱导缓解d15骨髓微小残留病(minimal residual disease,MRD)＞10％,临床危险度分层评为高危.入院初期曾并发颅内出血,因头颅CT及MR平扫+增强均未见脑实质改变,且诱导缓解中3次行腰椎穿刺术查脑脊液均未见异常,故评估为CNS1,经抢救平稳后于2019-8-13起按华南地区儿童白血病化疗协作组SCCLG-ALL-2016高危方案化疗,2020-8-01进入维持化疗.
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