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一例H3 G34突变的儿童弥漫性半球胶质瘤病例报道及文献复习

Tian Yufei,Zhang Liuchao,Tu Yiming,Pan Minhong,Liu Ning,Ji Jing

Biomedical Transformation（2022）

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Abstract
H3 G34突变的儿童弥漫性半球胶质瘤(Diffuse Hemispheric Glioma,DHG)是一种以组蛋白H3 G34基因突变为主要特征的高级别胶质瘤,临床罕见,预后不佳,且由于缺乏典型影像学表现,早期极易误诊.该亚型以手术治疗为主,尚无统一的放化疗方案.本文报道一例癫痫起病的左侧颞叶胶质瘤患儿,经手术全切肿瘤,术后病理证实为H3 G34突变的弥漫性半球胶质瘤.患儿术后恢复良好,随访6个月未见复发.
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