Study on the mechanism of Yupingfeng Powder in the treatment of non-small cell lung cancer based on network pharmacology and molecular docking method

Objective: The mechanism of Yupingfeng Powder in the treatment of non-small cell lung cancer was analyzed by network pharmacology and molecular docking method. Methods: Search the related literature and TCMSP database, query the chemical composition and action target of Yupingfeng powder, query the disease database of Genecards, OMIM, DisGeNET, Drugbank, etc., use "non-small cell lung cancer" as the keyword to search the disease-related target, select the intersection target with Yupingfeng powder as the research target, and use Cytoscape 3.7.2 software to construct the active component-target network map. The protein-protein interaction network map was constructed by using STRING database, and the treatment core targets were further screened by topological parameters, and GO analysis and KEGG signal pathway enrichment analysis were carried out. Finally, molecular docking was verified. Results: 37 active components of Yupingfeng Powder were screened, including 146 common targets and 44 core targets. GO analysis and KEGG analysis show that the core target participates in many biological processes such as angiogenesis and cell proliferation, and acts on a variety of signal pathways such as AGE-RAGE, IL-17, TNF, MAPK and so on. Molecular docking shows that the core compound has good docking activity with the target. Conclusion: Network pharmacological analysis shows that Yupingfeng powder in the treatment of non-small cell lung cancer involves multi-target and multi-pathway mechanism, and the drug and target have good docking activity, which can provide theoretical basis for follow-up experimental research.