肥胖与甲状腺癌的关系及其分子机制的研究进展

Objective:To summarize the latest advances in the study on the relationship between obesity and thyroid cancer and its molecular mechanism.Methods:Chinese and English databases, such as CNKI, Wanfang, and PubMed, were searched by using Chinese and English keywords, such as "肥胖" "甲状腺癌" "促甲状腺激素" "脂肪因子" "胰岛素抵抗" "脂联素" and "obesity" "thyroid cancer" "thyroid stimulating hormone" "adipokines" "insulin resistance" "adiponectin", for 901 articles published before 2021 regarding the relationship between obesity and thyroid cancer and its molecular mechanism. The final 37 papers were summarized and analyzed by eliminating the papers that were not in accordance with the content, had unavailable full text, and were repeated.Results:Epidemiological studies have confirmed that obesity is a risk factor for thyroid cancer. Recent studies have shown a correlation between obesity and the clinicopathologic features of thyroid cancer. The relationship between obesity and the prognosis of thyroid cancer is controversial, and the reasons may be related to the length of follow-up time and the prognosis of surgical intervention for thyroid cancer. The molecular mechanism of obesity and the occurrence and development of thyroid cancer remains controversial and needs to be further studied.Conclusions:Obesity is an important risk factor for thyroid cancer and is associated with the adverse clinicopathological factors of thyroid cancer. However, the relationship between obesity and the prognosis of thyroid cancer and the specific molecular mechanisms of obesity and the incidence of thyroid cancer are still unclear, which need to be studied further.