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维库溴铵致横纹肌溶解1例分析

WANG Bin,HUANG Huixuan,LI Jinfeng,ZHOU Guangjie,CHEN Weina,ZHANG Ailun,ZHANG Yuan

Journal of Pharmaceutical Research（2022）

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Abstract
1例61岁男性因手术给予"维库溴铵、舒芬太尼、依托咪酯、右美托咪定、七氟烷、丙泊酚"后第2天出现肌酸激酶升高.后因病情加重转入ICU,给予"维库溴铵20 mg+0.9％氯化钠注射液50 mL微量泵泵入"7 d后,患者尿量减少、呈棕色,实验室检查肌酸激酶最高可至18358 U·L-1,肌红蛋白>3000 ng·L-1,诊断为横纹肌溶解症.停用维库溴铵,给予补液、碱化尿液、利尿等治疗后7 d,实验室检查示肌酸激酶7212.4 U·L-1、肌红蛋白>3000 ng·L-1.15 d后患者尿量增多、尿色正常,实验室检查示肌酸激酶95 U·L-1、肌红蛋白506 ng·L-1.至出院患者未再出现尿量减少、颜色改变情况,肌酸激酶等实验室检查未再发生异常.
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