Structure-based peptide ligand design for improved epidermal growth factor receptor targeted gene delivery
European Journal of Pharmaceutics and Biopharmaceutics(2022)
Abstract
The epidermal growth factor receptor EGFR allows targeted delivery of macromolecular drugs to tumors. Its ligand, epidermal growth factor, binds EGFR with high affinity but acts mitogenic. Non-mitogenic peptides are utilized as targeting ligands, like the dodecapeptide GE11, although its low binding affinity warrants improvement.
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Key words
Polyplex,Transfection,Targeted gene delivery,EGFR,GE11
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