Probiotic-derived nanoparticles inhibit ALD through intestinal miR194 suppression and subsequent FXR activation.

Mengwei Jiang,Fengyuan Li,Yunhuan Liu,Zelin Gu,Lihua Zhang,Jiyeon Lee,Liqing He,Vatsalya Vatsalya,Huang-Ge Zhang,Zhongbin Deng,Xiang Zhang,Shao-Yu Chen,Grace L Guo,Shirish Barve,Craig J McClain,Wenke Feng

Hepatology (Baltimore, Md.)（2023）

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摘要

Our results demonstrated that gut microbiota-mediated miR194 regulation contributes to ALD pathogenesis and to the protective effects of LDNPs through modulating intestinal FXR signaling.

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