Design of the micropump and mass-transfer compartment of a microfluidic system for regular nonenzymatic glucose measurement

•An implantable integrated microfluidic device is designed for regular glucose measurement in diabetic patients.•The designed device has a sufficiently small size and enjoys the benefits of microdialysis method and nonenzymatic glucose measurement.•The mass-transfer compartment has the Recovery Factor of 72%, utilizing an array of 24 × 12 hollow microneedles.•The designed micropump is a piezoelectrically activated diaphragm-type pump which uses two passive flapper valves.•With a 2 Hz frequency and a 7.5 V input voltage, the micropump provides the flow rate of 1 μL/min.