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A Phase II Study of Preoperative Chemoradiotherapy with Capecitabine Plus Simvastatin in Patients with Locally Advanced Rectal Cancer.

Hyunji Jo,Seung Tae Kim,Jeeyun Lee,Se Hoon Park,Joon Oh Park,Young Suk Park,Ho Yeong Lim,Jeong Il Yu,Hee Chul Park,Doo Ho Choi,Yoonah Park,Yong Beom Cho,Jung Wook Huh,Seong Hyeon Yun,Hee Cheol Kim,Woo Yong Lee,Won Ki Kang

Cancer research and treatment（2023）

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摘要
The combination of 80 mg simvastatin with CRT and capecitabine did not improve pCR in patients with LARC, although it did not increase toxicity.
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关键词
Capecitabine,Pathologic complete response,Preoperative chemoradiotherapy,Rectal neoplasms,Simvastatin
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