Lipopolysaccharide-induced lung cell inflammation and apoptosis are enhanced by circ_0003420/miR-424-5p/TLR4 axis via inactivating the NF-κB signaling pathway

Hailing Yang,Chunmei Zhang,Zhongyan Zhao

Transplant Immunology（2022）

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摘要

•LPS-mediated endothelial injury is suppressed by circ_0003420 knockdown.•Circ_0003420 targets miR-424-5p to mediate the level of TLR4.•Circ_0003420 blocks the NF-κB signaling pathway via miR-424-5p/TLR4 axis.

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关键词

circ_0003420,miR-424-5p,TLR4,Sepsis-induced acute lung injury

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