Design and Self-Assembly of Sugar-Based Amphiphiles: Spherical to Cylindrical Micelles
LANGMUIR(2022)
Abstract
Sugar-based amphiphiles are a relevant natural alternative to synthetic ones due to their biodegradable properties. An understanding of their structure-assembly relationship is needed to allow the concrete synthesis of suitable derivatives. Her; four different mannose-derivative surfactants are characterized by pendant drop, dynamic light scattering, small-angle X-ray scattering, cryotransmission electron microscopy, and molecular dynamics techniques in aqueous media. Measurements denote hou the polysaccharide average degree of polymerization ((DP) over bar) and the addition of a hydroxyl group to the hydrophobic tail, and thus the presence of a second hydrophilic moiety, affect their self-assembly. A variation in the (DP) over bar of the amphiphile has no effect in the critical micelle concentration in contrast to a change in the hydrophobic molecular region. Moreover, high-(DP) over bar amphiphiles self-assemble into spherical micelles irrespective of the hydroxyl group presence. Low-(DP) over bar amphiphiles with only one hydrophilic moiety form cylindrical micelles, while the addition of a hydroxyl group to the tail leads to a spherical shape.
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Key words
amphiphiles,self-assembly,sugar-based
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