GWYRE: A Resource for Mapping Variants onto Experimental and Modeled Structures of Human Protein Complexes

Sukhaswami Malladi,Harold R Powell,Alessia David,Suhail A Islam,Matthew M Copeland,Petras J Kundrotas,Michael J E Sternberg,Ilya A Vakser

Journal of Molecular Biology（2022）

引用 3|浏览16

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摘要

•Structure of protein complexes is important for interpreting genetic variation.•Data on single amino acid variants is available from high-throughput sequencing.•Integrated modeling approach was applied to proteins and their complexes.•GWYRE resource incorporates predicted protein complexes with mapped mutations.

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关键词

structure prediction,protein docking,genotype to phenotype,amino acid mutations,genome-wide modeling

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