Astrocytic aquaporin 4 subcellular translocation as a therapeutic target for cytotoxic edema in ischemic stroke.

Brain edema is a common feature of several brain diseases(e.g.,stroke,traumatic brain injury,hydrocephalus,brain cancer,and brain infections).Brain edema leads to increased intracranial pressure and worsens outcomes in ischemic stroke patients.Conventional treatments to control brain edema,thus reducing intracranial pressure include different osmotherapeutics,hyperventilation,tromethamine,hypothermia,and barbiturate coma.