Steroid profile in dried blood spots by liquid chromatography tandem mass spectrometry: Application to newborn screening for congenital adrenal hyperplasia in China

Xia Zhan,Lianshu Han,Wenjuan Qiu,Xuefan Gu,Jun Guo,Siyu Chang,Yu Wang,Huiwen Zhang

Steroids（2022）

引用 2|浏览8

暂无评分

摘要

•A -LC-MS/MS assay for determination of six steroids in dried blood spots was developed.•Application of additional steroids allows -discrimination between 21-OHD and 11β-OHD.•Application of steroid profiling reduces false-positive results.•Second-tier testing improves the positive predictive value of CAH screening.

查看译文

关键词

Congenital adrenal hyperplasia,Liquid chromatography tandem mass spectrometry,Dried blood spot,Steroid profiling

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要