Gamma-oryzanol alleviates intervertebral disc degeneration development by intercepting the IL-1β/NLRP3 inflammasome positive cycle

Hui Xu,Zi-Han Dai,Gao-Lu He,Han-Chen Cai, Xuan-Yang Chen,Yan-Lin Chen,Cong Xu,Sun-Ren Sheng

Phytomedicine（2022）

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摘要

Gamma-oryzanol disrupt the IL-1β/NLRP3 inflammasome positive feedback loop by interfering with NF-κB signaling and ROS overproduction to alleviate IVDD in vivo and in vitro

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关键词

Gamma-oryzanol,Intervertebral disc degeneration,Nucleus pulposus,NLRP3 inflammasome,NF-κB

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