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alpha Klotho decreases after reduced weight-bearing from both spaceflight and hindlimb unloading

Jeffrey S Willey,Serena Aunon-Chancellor, Lauren A Miles,Joseph E Moore,Xiao W Mao, Robert W Wallace,Matthew C Foy

NPJ MICROGRAVITY（2022）

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Abstract
Alpha(alpha)Klotho, a soluble transmembrane protein, facilitates calcium-phosphorus homeostasis through feedback between bone and kidney and is a potential systemic biomarker for bone-kidney health during spaceflight. We determined if: (1) plasma alpha Klotho was reduced after both spaceflight aboard the ISS and hindlimb unloading (HU); and (2) deficiency could be reversed with exercise. Both spaceflight and HU lowered circulating plasma alpha Klotho: plasma alpha Klotho recovered with exercise after HU.
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Physiology,Predictive markers,Life Sciences,general,Classical and Continuum Physics,Biotechnology,Immunology,Space Sciences (including Extraterrestrial Physics,Space Exploration and Astronautics),Applied Microbiology
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