alpha Klotho decreases after reduced weight-bearing from both spaceflight and hindlimb unloading
NPJ MICROGRAVITY(2022)
Abstract
Alpha(alpha)Klotho, a soluble transmembrane protein, facilitates calcium-phosphorus homeostasis through feedback between bone and kidney and is a potential systemic biomarker for bone-kidney health during spaceflight. We determined if: (1) plasma alpha Klotho was reduced after both spaceflight aboard the ISS and hindlimb unloading (HU); and (2) deficiency could be reversed with exercise. Both spaceflight and HU lowered circulating plasma alpha Klotho: plasma alpha Klotho recovered with exercise after HU.
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Key words
Physiology,Predictive markers,Life Sciences,general,Classical and Continuum Physics,Biotechnology,Immunology,Space Sciences (including Extraterrestrial Physics,Space Exploration and Astronautics),Applied Microbiology
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