New approaches to the treatment of Age-Related Macular Degeneration (AMD)

Karl Csaky,Christine A Curcio,Robert F Mullins,Philip J Rosenfeld,James Fujimoto,Bärbel Rohrer, Ramiro Ribero,Goldis Malek,Nadia Waheed,Robyn Guymer,Gregory S Hageman,Hao Chen,Marie Csete

Experimental Eye Research（2022）

引用 5|浏览8

暂无评分

摘要

•Choroid and choriocapillaris are potential important targets of therapy early in AMD.•Macular vasculature pathology, like choriocapillaris flow deficits, can be measured using OCT-A.•Subretinal drusenoid deposits result from biogenesis pathways involved in lipid homeostasis.•How to target (over- or under-express) the HtrA1 gene associated with AMD is controversial.•Optimal gene therapies for AMD depend on retinal delivery site and specificity to retinal cell.

查看译文

关键词

Bruch's membrane,Choriocapillaris,Choroid,Complement inhibition,HTRA1 gene,Lipid dysregulation,Membrane attack complex,Optical coherence tomography angiography

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要