Serum Zinc Levels Are Associated with Obesity and Low-Density Lipoprotein Cholesterol in Mexican Adults.

Purpose: Little is known about the association between serum zinc (Zn) levels and obesity in the Mexican population. Therefore, we tested the association between serum Zn levels, obesity status, and serum lipid levels in a sample of Mexican adults. Methods: Anthropometric data and serum levels of total cholesterol, high-and low-density lipoprotein cholesterol (HDL-C and LDL-C, respectively), and triglycerides were analyzed in 96 Mexican adults. Serum Zn was measured with inductively coupled plasma mass spectrometry. An individual data meta-analysis of the association between serum Zn, overweight, and obesity status was performed in 172 adults from two different provinces in Mexico. Results: Serum Zn was negatively associated with body mass index (BMI, beta = -0.034 +/- 0.013, p = 2.0 x10(-6)) and obesity (odds ratio [OR] = 0.990, 95% confidence interval [CI]= 0.980-0.999, p = 3.4 x10(-5)). The association between Zn level and obesity in Mexican adults was confirmed with an individual data meta-analysis (OR= 0.977, 95% CI= 0.966-0.988, p = 3.4 x10(-5)). In addition, a significant interaction effect between serum Zn level and sex was observed on LDL-C level (beta = 7.010 +/- 3.295, p = 0.037). Serum Zn was negatively associated with LDL-C levels in women (beta = -0.188 +/- 0.074, p = 0.016). Conclusion: Our results confirm the negative association of serum Zn level with obesity. For the first time, we show a sex-specific association between serum Zn and LDL-C levels in a Mexican population. However, further studies are needed in larger and more varied Mexican cohorts to replicate and confirm our findings.