Pattern of frustration formation in the functional brain network

The brain is a frustrated system that contains conflictual link arrangements named frustration. The frustration as a source of disorder prevents the system from settling into low energy states and provides flexibility for brain network organization. In this research, we tried to identify the pattern of frustration formation in the brain at the levels of region, connection, canonical network, and hemisphere. We found that frustration formation has not a uniform pattern. Some subcortical elements have an active role in frustration formation, despite many low contributed cortical elements. Frustrating connections are mostly between-network types and triadic frustrations are mainly formed between three regions from three distinct canonical networks. Although there were no significant differences between brain hemispheres. We also did not find any robust differences between the frustration formation patterns of various lifespan stages. Our results may be interesting for those who study the organization of brain links and promising for those who want to manipulate brain networks. ### Competing Interest Statement The authors have declared no competing interest.