Flavivirus prM interacts with MDA5 and MAVS to inhibit RLR antiviral signaling.

Liyan Sui,Yinghua Zhao,Wenfang Wang,Hongmiao Chi,Tian Tian,Ping Wu,Jinlong Zhang,Yicheng Zhao,Zheng-Kai Wei,Zhijun Hou,Guoqiang Zhou,Guoqing Wang,Zedong Wang,Quan Liu

Cell & bioscience（2023）

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摘要

Our findings reveal the immune evasion mechanisms of flavivirus prM, which may contribute to understanding flavivirus pathogenicity, therapeutic intervention and vaccine development.

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关键词

Flavivirus,MAVS,MDA5,Precursor membrane protein,RLR signaling

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