Efficacy of hyaluronic acid gel and spray in healing of extraction wound: a randomized controlled study

OBJECTIVE: To evaluate the efficacy of 0.2% hyaluronic acid gel and 0.01% hyaluronic acid (HA) spray in the healing of extraction wounds using the ruler and digital planimetry method. PATIENTS AND METHODS: 30 systemically healthy female participants aged between 20-60 years requiring extraction were selected. Extraction sockets receiving 0.2% HA gel Gengigel 0.01% HA spray Gengigel". and where hyaluronic acid was excluded were allocated into three groups as test group A (HA gel group), test group B (HA spray group) and control group (without HA). Socket wound closure was measured post-operative on the day of extraction and 1-week post extraction using digital planimetry and ruler method. Patient satisfaction rate was evaluated for both the gel and spray. RESULTS: The wound closure with the ruler method was 43.01% for the control group, 67.01%, and 65.82% for the gel group and spray group respectively. The wound closure with the digital planimetry method was 47.97% for the control group, 69.08% for the gel group. and 66.94% for the spray group. The gel showed better results of wound closure as compared to the spray. However, the results were not statistically significant. CONCLUSIONS: Hyaluronic acid offers a beneficial effect in early post-operative healing after extraction.