Capsule-Based dry powder inhaler evaluation using CFD-DEM simulations and next generation impactor data

Lucilla C Almeida,Rahul Bharadwaj,Avi Eliahu,Carl R Wassgren,Karthik Nagapudi,Ariel R Muliadi

European Journal of Pharmaceutical Sciences（2022）

引用 4|浏览10

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摘要

•Coupled CFD-DEM model built to predict the performance of common capsule DPIs.•Model predicts particle dynamics that affect powder aerosol characteristics.•Formulation and DPI design interplay affecting fine aerosol generation identified.•Model results correlate with experimental cascade impactor data.•Design modifications to optimize capsule DPI performance are proposed.

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关键词

CFD-DEM,Dry powder inhalers,Discrete element method,Computational fluid dynamics,Inhalation drug delivery

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