Interspecies commensal interactions have nonlinear impacts on host immunity
Cell Host & Microbe(2022)
摘要
The impacts of individual commensal microbes on immunity and disease can differ dramatically depending on the surrounding microbial context; however, the specific bacterial combinations that dictate divergent immunological outcomes remain largely undefined. Here, we characterize an immunostimulatory Allo-baculum species from an inflammatory bowel disease patient that exacerbates colitis in gnotobiotic mice. Allobaculum inversely associates with the taxonomically divergent immunostimulatory species Akkermansia muciniphila in human-microbiota-associated mice and human cohorts. Co-colonization with A. muciniphila ameliorates Allobaculum-induced intestinal epithelial cell activation and colitis in mice, whereas Allobaculum blunts the A.muciniphila-specific systemic antibody response and reprograms the immunological milieu in mesenteric lymph nodes by blocking A.muciniphila-induced dendritic cell activation and T cell expansion. These studies thus identify a pairwise reciprocal interaction between human gut bacteria that dictates diver-gent immunological outcomes. Furthermore, they establish a generalizable framework to define the contex-tual cues contributing to the ???incomplete penetrance???of microbial impacts on human disease.
更多查看译文
关键词
gut microbiota,immunostimulatory commensals,mucosal immunity,inflammatory bowel disease,human gut bacteria,reciprocal epistasis,human microbiota-associated gnotobiotic mice,immunoglobulin A,IgA,IgA-Seq
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要