Bimetallic oxide nanozyme-mediated depletion of glutathione to boost oxidative stress for combined nanocatalytic therapy

Upon specific TME activation, POD-like, CAT-like, and GPx-like activities of CFOs given by bimetallic ion produced highly toxic ·OH, weakened the reducibility of TME, and relieved the tumor hypoxia. With NIR-II irradiation, the photonic hyperthermia of CFOs further enhanced the catalytic activities. The “three-in-one” nanozymes with POD-like, CAT-like, and GPx-like activities provide an alternative strategy.