ROS1 altered breast cancers - a distinctive molecular subtype of PR- metastatic breast cancers: Expanding the scope of targeted therapeutics.

Kritika Krishnamurthy,Arunima Deb,Sarah Alghamdi,Michael Schwartz,Mike Cusnir,Vathany Sriganeshan,Robert Poppiti

Breast disease（2022）

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摘要

This study highlights the significantly higher incidence of ROS1 gene alterations in metastatic PR- breast cancers, with STRING network analysis revealing higher nodal interaction in the nodal network comprised of PR and ROS1 exclusive of ER.

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关键词

ER+PR−,Metastatic breast cancer,ROS1,STRING network,TP53

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