Glycogen kinase 3 inhibitor nanoformulation as an alternative strategy to inhibit PD-1 immune checkpoint

Parisa Badiee,Michelle F Maritz,Benjamin Thierry

International Journal of Pharmaceutics（2022）

引用 4|浏览3

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摘要

•Hydrophobic pairing improved SB415286 GSK3 inhibitor loading in nanoparticles.•SB415286 nanoformulation inhibited PD-1 immune checkpoint expression in CAR-T cells.•Nanoformulation of GSK3 inhibitors is a promising alternative to PD-1 antibodies.

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关键词

Nanoparticle,Immune checkpoint,Glycogen synthase kinase 3,Immunotherapy,Oncology

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