Lympho-Hematopoietic Microenvironments and Fish Immune System

Simple Summary Teleost fish, the most abundant group of vertebrates, represent an excellent tool to establish possible correlations between the histological organization of their lymphoid organs and their immunological capacities. This approach allows us to analyze embryonic and larval lymphopoiesis, the remarkable organization of the teleost thymus, the role of the kidney as a true equivalent of the lympho-hematopoietic bone marrow of higher vertebrates, the mechanisms of antigen trapping in both ellipsoids and the so-called melano-macrophage centers (MMCs) and their relation with the generation of memory and the lack of germinal centers, and the extended development of the lymphoid tissue associated to mucosae. In the last 50 years information on the fish immune system has increased importantly, particularly that on species of marked commercial interest (i.e., salmonids, cods, catfish, sea breams), that occupy a key position in the vertebrate phylogenetical tree (i.e., Agnatha, Chondrichtyes, lungfish) or represent consolidated experimental models, such as zebrafish or medaka. However, most obtained information was based on genetic sequence analysis with little or no information on the cellular basis of the immune responses. Although jawed fish contain a thymus and lympho-hematopoietic organs equivalents to mammalian bone marrow, few studies have accounted for the presumptive relationships between the organization of these cell microenvironments and the known immune capabilities of the fish immune system. In the current review, we analyze this topic providing information on: (1) The origins of T and B lymphopoiesis in Agnatha and jawed fish; (2) the remarkable organization of the thymus of teleost fish; (3) the occurrence of numerous, apparently unrelated organs housing lympho-hematopoietic progenitors and, presumably, B lymphopoiesis; (4) the existence of fish immunological memory in the absence of germinal centers.