Inflammatory comorbidities: to train or not to train?
TRENDS IN IMMUNOLOGY(2022)
Abstract
Inflammatory stimuli reprogram innate immune cells to generate rigorous responses to future challenge with heterologous stimuli through trained immunity. Li et al. show that training of hematopoietic stem cells ( HSCs) in the bone marrow primes cells to generate more inflammatory myeloid progeny and, thereby, mechanistically links inflammatory comorbidities.
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Key words
inflammatory comorbidities
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