The mechanism of Jianpi Jiedu decoction in treating psoriasis vulgaris in mice with spleen deficiency

This study is to investigate the role and mechanism of Jianpi Jiedu decoction in psoriasis vulgaris. Seventy healthy male ICR mice were divided into control group, Acitretin capsule group, Jianpi decoction group, Jiedu decoction group, Jianpi Jiedu decoction group, spleen deficiency model group and psoriasis vulgaris with spleen deficiency group. The expression levels of IFN-γ, IL-6 and IL-17 in the drug intervention groups were significantly different from those in the control, the spleen deficiency model and the psoriasis vulgaris with spleen deficiency groups (P < 0.05). The psoriasis vulgaris with spleen deficiency group had obvious psoriasis vulgaris-like skin lesions, which were attenuated in the Jianpi Jiedu decoction group. The mRNA levels of STAT3 and STAT5 in Jianpi Jiedu decoction group were significantly lower than those in Jianpi decoction and Jiedu decoction groups (P < 0.05). At the protein level, STAT3 and STAT5 had no statistical significance among groups (P > 0.05). The protein expression levels of p-STAT3 and p-STAT5 in Jianpi Jiedu decoction group were significantly lower than those in Jianpi decoction and Jiedu decoction groups (P < 0.05). Conclusively, Jianpi Jiedu decoction may exert treatment effects on psoriasis vulgaris in mice with spleen deficiency via regulating JAKS/STATS pathway.