A reduced form of nicotinamide riboside protects the cochlea against aminoglycoside-induced ototoxicity by SIRT1 activation

Jia Fang,Hongmin Wu,Jianning Zhang,Song Mao,Haosong Shi,Dongzhen Yu,Zhengnong Chen,Kaiming Su,Yazhi Xing,Hongjun Dong,Haibo Shi

Biomedicine & Pharmacotherapy（2022）

Cited 9|Views15

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Abstract

•NRH effectively protects against aminoglycoside-induced ototoxicity.•NRH alleviates aminoglycoside-induced HC damage via SIRT1 activation.•NRH has superior ability to increase NAD+ in the cochlea than NR.

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Key words

ABR,AK,ARHL,AUC0-t,AUC0-∞,BLB,Cmax,HC,HCs,IHCs,LC-MS/MS,MRSA,MRT,NA,NAD+,NAM,NIHHL,NIHL,NMDA,NMN,NMNH,NR,NRH,NRKs,OHCs,ROS,SGNs,SIRTs,SPTAN1,T1/2,Tmax,Trp

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