路易体痴呆前期的概念和研究性诊断标准

Chinese Journal of Neuroimmunology and Neurology(2022)

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Abstract
路易体痴呆(dementia with Lewy bodies,DLB)是除阿尔茨海默病外引起痴呆的第二位神经变性疾病,以波动性认知障碍、帕金森症、快速眼动期睡眠行为紊乱及视幻觉等为核心临床特征,临床上可分为无症状期、痴呆前期和痴呆期.DLB痴呆前期是指在达到痴呆诊断标准前出现的DLB相关临床表现,常见轻度认知障碍 DLB(MCI-LB)、谵妄起病 DLB(delirium-onset DLB)以及精神症状起病 DLB(psychiatric-onset DLB)三种类型.本文主要综述了 DLB痴呆前期临床特征及研究性诊断标准,期望有助于DLB早期识别和干预.
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