Detection of gene mutation related to non-small cell lung cancer using next-generation sequencing
Tạp chí Khoa học và Công nghệ Việt Nam(2022)
Abstract
To date, lung cancer is one of the most well-understood cancers in terms of molecular mechanisms, with high incidence and mortality rates in the population. Detecting lung cancer-related gene mutations plays a vital role in offering targeted therapy, thereby improving the progression-free survival and overall survival rates of patients. This study aims to identify some clinical features and factors related to non-small cell lung cancer and detect some types of gene mutations related to non-small cell lung cancer by new-generation sequencing techniques on biopsy tissue samples of patients. 40 patients with non-small cell lung cancer who were tested to detect gene mutations in biopsy tissue samples by next-generation sequencing. Results showed the majority of patients were male (70%), over 60 years old (65%), in the late stage (100%), and have not received any treatment (85%). 26/40 patients have detected mutations, in which mutations are most frequently in EGFR (27.5%) and KRAS (20.0%), followed by ALK (12.5%), BRAF (5.0%), did not detect mutations on NRAS, ROS1, and PIK3CA. The rate of mutations related to the target drug susceptibility was quite high, no resistant mutants were detected.
MoreTranslated text
Key words
cell lung cancer,gene mutation,non-small,next-generation
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined