Uromodulin and its association with urinary metabolites: the German Chronic Kidney Disease Study.

Helena Bächle,Peggy Sekula,Pascal Schlosser,Inga Steinbrenner,Yurong Cheng,Fruzsina Kotsis,Heike Meiselbach,Helena Stockmann,Sebastian Schönherr,Kai-Uwe Eckardt,Olivier Devuyst,Jürgen Scherberich,Anna Köttgen,Ulla T Schultheiss

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association（2023）

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摘要

We identified urinary metabolites associated with urinary and serum uromodulin. The sUMOD and the sMS were associated with lower risk of adverse kidney events among CKD patients. Higher levels of sUMOD and sMS may reflect a higher number of functional nephrons and therefore a reduced risk of adverse kidney outcomes.

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关键词

CKD,metabolites,nephron mass,uromodulin

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