Efficacy of Kushen decoction (???) on high-fat-diet-induced hyperlipidemia in rats

Zhang Jiri Mutu, Liang Shilong,Nie Peng, Liao Yong'an, A I Qinying,Yan Xiaojun,Liu Hongning,J I Yanhua,Zeng Zhijun

JOURNAL OF TRADITIONAL CHINESE MEDICINE（2022）

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Abstract

OBJECTIVE: To investigate the efficacy and underlying mechanisms of action of Kushen decoction on high-fat-diet-induced hyperlipidemia in rats using RNA-seq technology. METHODS: The efficacy of a Kushen decoction (?????????), at a concentration of 1 mL/g of crude medicine prepared according to the method commonly used in clinical practice, was investigated on 24 specific pathogen-free male Sprague-Dawley rats. Liver tissues were compared using RNA-Seq technology. The differentially expressed genes were further investigated by real-time fluorescent

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Key words

liver, hyperlipidemias, RNA-seq, transcriptome, Kushen decoction

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