Development of retinal atrophy after subretinal gene therapy with voretigene neparvovec.

Felix Friedrich Reichel,Immanuel Seitz,Fabian Wozar,Spyridon Dimopoulos,Ronja Jung,Melanie Kempf,Susanne Kohl,Friederike Charlotte Kortüm,Saskia Ott,Lisa Pohl,Krunoslav Stingl,Karl Ulrich Bartz-Schmidt,Katarina Stingl,M Dominik Fischer

The British journal of ophthalmology（2022）

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摘要

Subretinal injection of VN can lead to RPE atrophy with consequent photoreceptor loss in and outside of the bleb area. Fundus autofluorescence is an important tool to monitor atrophic changes in patients after gene therapy. Interestingly, while areas of atrophy also included central areas, the functional benefits of the treatment did not appear to be affected and remained stable.

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关键词

Degeneration,Drugs,Retina,Treatment Surgery

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