Small-molecule modulators of protein–RNA interactions
Current Opinion in Chemical Biology(2022)
摘要
Protein–RNA interactions (PRIs) play crucial roles in diverse cellular pathways, from transcription to liquid–liquid phase separation, and its dysregulation is associated with a wide range of human disorders. Therefore, there is great emphasis on discovering small-molecule modulators that target unexplored PRIs by developing robust PRI assays. In particular, targeting PRIs could offer innovative solutions to expand the druggable genome, as only a small portion of protein-coding genes are currently targeted by drugs. This review describes the therapeutic potential of targeting PRIs using small molecules, biochemical and cell-based experimental tools for observing PRIs, and several PRI modulators. We also highlight emerging technologies and the challenges in developing PRI modulators.
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关键词
Protein–RNA interaction,Small-molecule modulators,Assay platform,High-throughput screening
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