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Profiling the biochemical lysosomal activities in blood of patients with multiple system atrophy

Tatiana Usenko,Anastasia Bezrukova,Katerina Basharova,Darya Bogdanova,Ekaterina Palchikova,Konstantin Senkevich,Elizaveta Gracheva,Natalia Zalutskaya,Irina Miliukhina,Ekaterina Zakharova,Sofya Pchelina

JOURNAL OF THE NEUROLOGICAL SCIENCES（2021）

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Abstract
Existed criteria cannot reliably differentiate of multiple system atrophy (MSA)) with other synucleinophaties (Parkinson's disease (PD), dementia with Lewy bodies (DLB)) due to the unknown molecular mechanism. Last data suggest that lysosomal dysfunction may play a pivotal role in the pathogenesis of synucleinopathies.The objective of the current study was to define a biochemical profile that could distinguish MSA with other synucleinophaties.
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biochemical lysosomal activities
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