Sensory changes in postural tachycardia syndrome compared to chronic migraine

Postural tachycardia syndrome (PoTS) and migraine frequently present together in clinical practice. Up to 90% of PoTS patients report headaches of some kind, with migrainous headaches as the most widely recognized primary headache in this cohort. Given this comorbidity, pathophysiological interaction is possible, which could identify key features of disease pathophysiology and targeted treatment interventions. We hypothesized that migrainous and non-migrainous PoTS subjects would show features of central sensitization, including allodynia and photophobia.