Evaluation of 10°C as the optimal storage temperature for aspiration-injured donor lungs in a large animal transplant model

Etienne Abdelnour-Berchtold,Aadil Ali,Cristina Baciu,Erika L Beroncal,Aizhou Wang,Olivia Hough,Mitsuaki Kawashima,Manyin Chen,Yu Zhang,Mingyao Liu,Tom Waddell,Ana C Andreazza,Shaf Keshavjee,Marcelo Cypel

JOURNAL OF HEART AND LUNG TRANSPLANTATION（2022）

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摘要

We demonstrate 10°C as a potentially superior storage temperature for injured donor lungs in a pig model when compared to the current clinical standard (4°C) and immediate transplantation. Continuing protective metabolism at 10°C for donor lungs may result in better transplant outcomes.

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关键词

lung transplantation,organ preservation,mitochondrial health,ischemia reperfusion injury (IRI),inflammasome,necroptosis

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