A Neoprzewaquinone Analogue from Salvia miltiorrhiza Bunge

(3R,3'R) 2,2',3,3'-tetrahydroneoprzewaquinone A (1), a previously undescribed neoprzewaquinone analogue, was isolated from the root of Salvia miltiorrhiza Bunge. Its absolute configuration was elucidated by comprehensive analyses of spectra including NMR and MS combined with ECD calculations. MTT assay indicated that 1 can inhibit the proliferation of MV-4-11, TMD-8, MOLM-13, and H460 cell lines with IC50 values of 2.21 mu M, 2.48 mu M, 3.39 mu M, and 2.02 mu M respectively. (C) 2022 ACG Publications. All rights reserved.