Solvothermal synthesis of a new heterometallic Cd-Ba compound based on terephthalic acid: Catalytic property and therapeutic effect on diabetes

Presented is a new heterometallic compound, namely [Cd2Ba2(pdc)(4)(H2O)(4)(DMA)(2)]}(n)center dot n(H2O) (1, H(2)pdc = terephthalic acid, DMA is N, N '-dimethylacetamide), which was created with the solvothermal reaction. The architectural analysis of X-ray indicated that the 1 reveals a three-dimensional skeleton according to one-dimensional infinite chains. After removal of the free along with coordinated solvent molecules, it contains 49.8% solvent-accessible volume and unsaturated coordination sites. The solvent-free form of 1 exhibits excellent catalytic effect for the addition reaction between diethylzinc and benzaldehyde. Its therapeutic effect and mechanism exploration on diabetes was conducted in this present research. Firstly, the abundance of intestinal flora in the gut was detected with real time RT-PCR assay. Besides, the measurement of the levels of sugar was conducted with blood glucose meter in the T2DM animal after compound treatment. The cytotoxicity of the 1 was evaluated with CCK-8 assay.