ON-CHIP COMPARTMENTALIZED VASCULAR BED PRESERVES KIDNEY ORGANOID DIFFERENTIATION
2022 IEEE 35TH INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS CONFERENCE (MEMS)(2022)
摘要
On-chip vascular bed (VB) system, which enables a three-dimensional tissue to be cultured on a perfusable vasculature, is useful to overcome the current limitation of a kidney organoid (KO): the lack of functional vasculature. However, there are two main hurdles to apply VB system to a KO culture. One is an air-liquid interface that is necessary for in vitro culture of KOs. The other is the optimum medium condition for organoid development. In this study, we proposed a modified VB system to satisfy these two requirements. We confirmed that our VB system preserved KO differentiation.
更多查看译文
关键词
Kidney organoid, On-chip vascular bed, Vascularization, Air-liquid interface culture, Microphysiological system
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要