Rheumatoid Factor Recognizes Specific Domains of the IgG Heavy Chain Complexed with HLA Class II Molecules.

ARTHRITIS & RHEUMATOLOGY(2023)

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Abstract
The CH1 domain of IgGH binds to the RA-susceptible HLA-DR molecule and is expressed on the cell surface. RF specifically recognizes the CH3 domain of the IgGH/HLA-DR4 complex.
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Key words
RA, RF, IgG heavy chain, autoantigens and autoantibodies, major histocompatibility complex
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